White matter aging involves structural and functional decline in myelinated nerve fibers that enable rapid communication between brain regions. Aging white matter shows reduced integrity, altered connectivity, and slowed signal transmission. These changes affect cognitive processing speed, coordination, and executive function. White matter aging is influenced by vascular insufficiency, inflammation, and metabolic stress. Disruption of long-range neural communication contributes to cognitive slowing and reduced network efficiency. Understanding white matter aging emphasizes connectivity preservation as essential for maintaining brain function during aging.
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