This Cellular Senescence and Senolytics session focuses on the role of cellular senescence as a key driver of age-related tissue dysfunction and chronic disease. It will examine senescence-inducing stressors, senescence-associated secretory phenotype (SASP) pathways, and the crosstalk between senescent cells and surrounding microenvironments. Presentations will address methods to detect and characterize senescent cell populations in vivo, including single-cell omics and imaging approaches. The track will highlight preclinical and emerging clinical data on senolytic and senomorphic therapies, their mechanisms of action, and safety considerations. Contributions exploring senescence in specific organs, regenerative niches, and the immune system are particularly encouraged to inform rational intervention strategies.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom