World Aging & Longevity Conference
October 08-10, 2026
Thymic Involution
Thymic involution refers to progressive shrinkage and functional decline of the thymus that begins early in adulthood. The thymus is responsible for producing naïve T lymphocytes essential for adaptive immune diversity. With thymic involution, output of naïve T cells decreases, limiting immune responsiveness to new antigens. This decline contributes to reduced vaccine efficacy and increased infection risk with age. Thymic involution also promotes accumulation of memory and senescent T cells, reducing immune flexibility. Loss of thymic function is a central driver of immune aging and contributes to chronic inflammation and immune imbalance. Understanding thymic involution supports strategies aimed at restoring immune diversity and resilience.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
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Kenneth R Pelletier, University of California School of Medicine, United States
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Arthur J Siegel, McLean Hospital, United States
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