Telomere shortening is a hallmark of cellular aging caused by the progressive loss of telomeric DNA during cell division. Telomeres protect chromosome ends from degradation and fusion, but they shorten with each replication cycle due to incomplete DNA synthesis. When telomeres reach a critically short length, cells enter replicative senescence or undergo apoptosis. Telomere shortening is influenced by oxidative stress, inflammation, and lifestyle factors such as smoking, poor diet, and chronic stress. Shortened telomeres are associated with aging-related diseases, reduced regenerative capacity, and increased mortality risk. Telomere length is widely studied as a biomarker of cellular aging and cumulative biological stress.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom