Systems aging describes the coordinated decline of interconnected physiological systems over time. Aging does not occur in isolation within individual organs; instead, changes in one system influence others through metabolic, immune, endocrine, and neural signaling. Systems aging involves dysregulation of homeostasis, reduced adaptability to stress, and impaired communication between tissues. Chronic inflammation, metabolic imbalance, and neuroendocrine alterations play central roles in systemic aging. As systems lose coordination, resilience decreases and vulnerability to disease increases. Systems aging emphasizes the importance of integrative approaches to aging research that consider organism-wide interactions rather than single pathways. This perspective supports holistic strategies for promoting healthy aging.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom