Stem cell niche aging refers to age-associated changes in the microenvironment that supports stem cell maintenance and function. The niche provides physical support, signaling cues, and metabolic regulation essential for stem cell behavior. With aging, niche composition and signaling become altered due to inflammation, fibrosis, vascular decline, and extracellular matrix remodeling. These changes impair stem cell self-renewal and differentiation, even when stem cells themselves remain viable. Stem cell niche aging contributes to reduced tissue regeneration and delayed repair. Understanding niche aging emphasizes that stem cell dysfunction arises from both intrinsic cellular changes and extrinsic environmental deterioration. Targeting niche integrity is critical for restoring regenerative capacity during aging.
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