Stem cell functional decline refers to reduced ability of stem cells to self-renew, differentiate, and regenerate tissues with advancing age. Aging stem cells accumulate molecular damage, exhibit altered metabolism, and show reduced responsiveness to regulatory signals. These changes limit regenerative output and tissue maintenance. Stem cell functional decline affects multiple organs, including blood, muscle, brain, and skin. It contributes to delayed healing, organ degeneration, and increased disease vulnerability. Understanding stem cell functional decline is essential for developing regenerative strategies that preserve tissue integrity and promote healthy aging.
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Thomas J Webster, Brown University, United States
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