Single cell aging examines aging processes at the resolution of individual cells rather than bulk tissues. Aging is highly heterogeneous, with neighboring cells exhibiting distinct aging states. Single-cell analyses reveal shifts in cell identity, transcriptional noise, senescence burden, and lineage imbalance with age. This approach uncovers rare but influential cell populations that drive tissue dysfunction. Single cell aging also highlights how aging alters cell-cell communication and tissue organization. Understanding aging at single-cell resolution refines models of tissue decline and regenerative failure. It provides critical insight into how cellular diversity and dysfunction accumulate over time.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom