Senolytics are interventions that selectively eliminate senescent cells that accumulate with age. Senescent cells contribute to tissue dysfunction through inflammatory signaling and impaired regeneration. By clearing these cells, senolytics aim to reduce chronic inflammation, restore tissue homeostasis, and improve functional outcomes. Senolytic strategies target vulnerabilities unique to senescent cells while sparing healthy cells. Research has shown that removal of senescent cells can improve physical function and delay age-related decline in experimental systems. Senolytics represent a targeted approach to addressing one of the fundamental drivers of aging. Understanding senolytics supports development of therapies that enhance tissue health and resilience.
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