World Aging & Longevity Conference
October 08-10, 2026
Senescence-Associated Secretory Phenotype (SASP)
The senescence-associated secretory phenotype (SASP) refers to the bioactive molecules secreted by senescent cells, including pro-inflammatory cytokines, chemokines, growth factors, and proteases. SASP factors alter the tissue microenvironment by promoting inflammation, extracellular matrix remodeling, and disruption of normal cellular communication. While transient SASP activity can aid wound healing and immune surveillance, chronic SASP signaling contributes to age-related tissue degeneration and systemic inflammation. Persistent SASP promotes the spread of senescence to neighboring cells and accelerates aging processes. SASP is strongly associated with “inflammaging,” a hallmark of aging linked to chronic disease. Targeting SASP components through senomorphic therapies is a promising approach to reduce age-related inflammation without eliminating senescent cells entirely.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom