World Aging & Longevity Conference
October 08-10, 2026
Replicative Senescence
Replicative senescence occurs when cells permanently stop dividing after reaching a finite number of cell divisions. This process is primarily driven by progressive telomere shortening during repeated DNA replication. Once telomeres become critically short, cells activate DNA damage responses that trigger senescence to preserve genomic stability. Replicative senescence is especially relevant in tissues with high cellular turnover, such as skin, blood, and the gastrointestinal tract. Although it serves as a tumor-suppressive mechanism, replicative senescence contributes to reduced tissue regeneration and functional decline with age. Accumulation of replicatively senescent cells is associated with aging phenotypes and age-related diseases. Understanding replicative senescence is essential for developing strategies to maintain regenerative capacity during aging.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom