Proteomic aging clocks use circulating or tissue protein profiles to estimate biological age. Protein abundance reflects functional state of physiological systems. Proteomic aging clocks capture inflammatory status, metabolic regulation, and tissue integrity. These clocks provide clinically relevant insights due to accessibility of blood-based measurements. Proteomic clocks integrate systemic aging signals across organs. Understanding proteomic aging clocks supports translation of aging biomarkers into clinical practice.
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