Proteomic aging describes age-associated changes in protein abundance, structure, modification, and interaction networks. Aging cells exhibit altered protein synthesis rates, increased protein damage, and reduced efficiency of protein quality-control systems. These changes lead to accumulation of misfolded or dysfunctional proteins that disrupt cellular processes. Proteomic aging affects signaling pathways, metabolic enzymes, structural proteins, and stress-response systems. Post-translational modifications also shift with age, altering protein function and stability. Proteomic aging reflects cumulative effects of oxidative stress, impaired degradation, and declining proteostasis. Understanding proteomic aging helps connect molecular damage to functional outcomes and supports discovery of protein-based aging biomarkers and therapeutic targets.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom