World Aging & Longevity Conference
October 08-10, 2026
Poly ADP Ribose Polymerase Aging
Poly ADP ribose polymerase aging refers to age-related changes in activity of PARP enzymes that detect DNA damage and initiate repair signaling. PARPs play a critical role in maintaining genomic stability by sensing DNA strand breaks and recruiting repair machinery. With aging, increased DNA damage leads to chronic PARP activation. While protective in acute settings, persistent PARP activity consumes cellular NAD reserves, impairing energy metabolism and mitochondrial function. Poly ADP ribose polymerase aging therefore links genome maintenance with metabolic decline. Excessive PARP activity contributes to cellular stress, reduced repair efficiency, and functional deterioration. Understanding PARP aging highlights a trade-off between DNA repair and metabolic stability and identifies PARP regulation as a key factor influencing aging trajectories.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
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Kenneth R Pelletier, University of California School of Medicine, United States
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Thomas J Webster, Brown University, United States
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Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom