Physiological aging describes gradual decline in the functional capacity of cells, tissues, and organ systems over time. This process reflects cumulative molecular damage, reduced regenerative potential, and altered regulatory signaling. Physiological aging affects cardiovascular efficiency, metabolic balance, immune competence, and neuromuscular function. Unlike disease, physiological aging occurs universally, although its rate varies widely among individuals. Early physiological changes may be subtle and compensated, but reduced reserve becomes evident under stress. Physiological aging underlies increased vulnerability to illness and slower recovery. Understanding physiological aging provides insight into mechanisms driving functional decline and supports interventions aimed at preserving system reserve and adaptability throughout the lifespan.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom