HYBRID EVENT: Join us in person in Tokyo, Japan or attend virtually from anywhere.
World Aging & Longevity Conference
October 08-10, 2026
PARP Activation Aging
PARP Activation Aging
PARP activation aging describes sustained activation of PARP enzymes driven by accumulated DNA damage during aging. Chronic activation reflects increased genomic stress from oxidative damage, replication errors, and environmental insults. Persistent PARP signaling depletes NAD pools, reducing activity of metabolic and longevity-associated enzymes. This depletion compromises mitochondrial energy production and stress resistance. PARP activation aging promotes cellular dysfunction, inflammation, and senescence. It represents a mechanistic link between DNA damage burden and metabolic failure. Understanding PARP activation aging supports strategies aimed at restoring balance between genome repair and cellular energy preservation.
Committee Members
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom WALC 2026 Speakers
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom