Parkinson disease aging reflects the strong association between advancing age and vulnerability of dopaminergic neurons. Aging contributes to mitochondrial dysfunction, oxidative stress, and impaired protein clearance that promote neurodegeneration. Parkinson disease aging involves progressive motor impairment, cognitive changes, and autonomic dysfunction. Age-related decline in neuronal resilience accelerates disease onset and progression. Understanding Parkinson disease within an aging biology framework highlights shared mechanisms between normal aging and neurodegeneration. This perspective supports interventions targeting cellular maintenance and stress resistance.
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