World Aging & Longevity Conference
October 08-10, 2026
Paracrine Signaling Aging
Paracrine signaling aging refers to age-associated alterations in local cell-to-cell communication mediated by secreted factors acting over short distances. In healthy tissues, paracrine signals coordinate regeneration, immune responses, and tissue maintenance. With aging, the composition and timing of these signals become dysregulated due to cellular stress, inflammation, and senescence. Altered paracrine signaling promotes chronic inflammation, impairs stem cell activation, and disrupts tissue homeostasis. Senescent cells contribute strongly by releasing pro-inflammatory mediators that affect neighboring cells. Paracrine signaling aging amplifies local dysfunction and propagates aging phenotypes within tissues. Understanding paracrine signaling aging highlights how aging spreads through tissues via altered communication rather than isolated cellular failure.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom