World Aging & Longevity Conference
October 08-10, 2026
p53 Aging
p53 aging refers to age-dependent changes in activity of the tumor suppressor protein p53, a central regulator of genomic integrity. p53 responds to DNA damage, oxidative stress, and oncogenic signals by inducing cell cycle arrest, senescence, or apoptosis. With aging, chronic activation of p53 helps prevent cancer but also promotes tissue degeneration and stem cell decline. Elevated p53 activity shifts cellular priorities from growth toward damage control, reducing regenerative capacity. Dysregulated p53 signaling contributes to cellular senescence, inflammation, and functional decline. p53 aging illustrates the trade-off between cancer protection and tissue maintenance. Understanding p53 aging is essential for balancing genome stability with longevity and tissue regeneration.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom