World Aging & Longevity Conference
October 08-10, 2026
p21 Aging
p21 aging describes age-related activation of the cyclin-dependent kinase inhibitor p21, a key mediator of cell cycle control. p21 is induced in response to cellular stress, DNA damage, and activation of tumor suppressor pathways. During aging, sustained p21 expression promotes cell cycle arrest to prevent propagation of damaged cells. While this mechanism supports genomic stability, chronic p21 activation contributes to reduced cell proliferation and impaired tissue renewal. p21 aging is closely linked to cellular senescence, stress responses, and declining regenerative potential. Increased p21 activity affects stem cell function and tissue maintenance, particularly in high-turnover organs. Studying p21 aging provides insight into how protective cell cycle checkpoints contribute to aging phenotypes through long-term suppression of cellular renewal.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom