Osteoporosis aging refers to age associated weakening of bone characterized by reduced bone density and compromised microarchitecture. Aging disrupts balance between bone formation and bone resorption, favoring net bone loss. Hormonal changes, reduced mechanical loading, impaired calcium absorption, and inflammation contribute to skeletal fragility. Osteoporosis aging increases fracture risk, particularly in the hip, spine, and wrist. Fractures in older adults are associated with significant disability, morbidity, and mortality. Osteoporosis aging represents a major public health concern due to its impact on mobility and independence. Understanding bone deterioration through an aging biology framework supports preventive strategies aimed at preserving skeletal strength.
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