Osteoclast aging refers to age-related changes in bone-resorbing cells responsible for degrading mineralized bone. Aging alters osteoclast number, activity, and regulation. Increased inflammatory signaling often enhances osteoclast activity, accelerating bone resorption. Dysregulated osteoclast aging disrupts balance between resorption and formation, contributing to bone loss. Altered osteoclast function also affects bone quality and microarchitecture. Understanding osteoclast aging provides insight into mechanisms driving skeletal fragility and highlights targets for preserving bone integrity during aging.
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