Organismal aging refers to integrated aging of the entire organism resulting from interactions among cellular, tissue, and system-level changes. It reflects coordination and communication among organs rather than isolated decline in individual systems. Organismal aging manifests as reduced resilience, slower recovery, and increased susceptibility to stress. Dysregulation in one system can propagate dysfunction across others, amplifying decline. Organismal aging emphasizes the systemic nature of aging biology, where inter-organ signaling, immune regulation, and metabolic balance play central roles. Understanding organismal aging supports holistic approaches to aging intervention that target system integration rather than single pathways or organs.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom