Nutrient sensing aging refers to age-related dysregulation of pathways that detect nutrient availability and regulate cellular growth, metabolism, and repair. Key nutrient sensing systems include mTOR, AMPK, insulin, and IGF 1 pathways. Aging disrupts these systems, leading to excessive growth signaling and reduced maintenance capacity. Impaired nutrient sensing accelerates cellular damage accumulation and disease risk. Proper regulation of nutrient sensing supports metabolic balance, stress resistance, and longevity. Nutrient sensing aging provides a unifying framework linking diet, metabolism, and aging mechanisms.
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