The nine hallmarks of aging represent conserved biological processes that collectively define aging across species. These hallmarks explain how damage accumulates at molecular, cellular, and tissue levels over time. They include primary damage drivers, antagonistic responses, and integrative failures that ultimately impair organismal function. The nine hallmark model emphasizes interactions among aging mechanisms rather than isolated effects. It has become a foundational concept in aging biology, helping researchers classify aging pathways and prioritize therapeutic targets. Understanding the nine hallmarks of aging supports the development of interventions aimed at delaying multiple age-related conditions simultaneously rather than treating diseases individually.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom