Neuronal plasticity aging refers to reduced ability of neurons to adapt structurally and functionally in response to experience or injury. Plasticity supports learning, memory formation, and recovery following stress. Aging diminishes synaptic remodeling, dendritic growth, and activity-dependent signaling. These changes limit adaptive capacity and impair cognitive flexibility. Neuronal plasticity aging is driven by altered neurotransmitter signaling, inflammation, and reduced neurotrophic support. Declining plasticity increases vulnerability to cognitive impairment. Understanding neuronal plasticity aging highlights the importance of maintaining adaptive signaling mechanisms for brain resilience across the lifespan.
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