Neuroendocrine aging describes age-related alterations in interactions between the nervous system and endocrine regulation. This system coordinates stress responses, metabolism, reproduction, and circadian rhythms. With aging, neuroendocrine signaling becomes dysregulated, reducing adaptability to internal and external stressors. Altered neuroendocrine aging affects hormone release patterns, feedback sensitivity, and central regulation. These changes influence metabolism, immune balance, cognitive function, and emotional regulation. Neuroendocrine aging plays a central role in systemic aging and resilience decline. Understanding this process supports strategies that preserve regulatory integration and adaptive capacity across the lifespan.
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