World Aging & Longevity Conference
October 08-10, 2026
NAD Decline Aging
NAD decline aging describes the progressive reduction in intracellular NAD levels that occurs with advancing age. This decline results from decreased NAD biosynthesis and increased NAD consumption driven by DNA damage, inflammation, and metabolic stress. Lower NAD availability impairs mitochondrial energy production, weakens DNA repair capacity, and reduces activity of longevity-associated enzymes. NAD decline aging contributes to fatigue, metabolic dysfunction, neurodegeneration, and reduced tissue resilience. Because NAD supports fundamental cellular processes, its decline amplifies multiple hallmarks of aging simultaneously. Understanding NAD decline aging has become central to longevity research, as restoring NAD levels may improve metabolic health, cellular repair, and overall physiological function during aging.
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom