Muscle stem cell aging refers to the functional decline of satellite cells responsible for skeletal muscle regeneration. Aging reduces satellite cell number, activation, and proliferative capacity, contributing to muscle loss and weakness. Altered signaling, chronic inflammation, and niche dysfunction impair muscle stem cell responsiveness. Accumulation of cellular damage further limits regenerative potential. Muscle stem cell aging plays a major role in sarcopenia and reduced physical performance in older adults. Targeting muscle stem cell aging is a key strategy to preserve mobility, strength, and independence during aging.
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Kenneth R Pelletier, University of California School of Medicine, United States
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