Molecular aging refers to age-related changes at the molecular level that impair cellular and organismal function. These include DNA mutations, epigenetic drift, protein misfolding, lipid oxidation, and altered RNA processing. Over time, the accumulation of molecular damage overwhelms repair and quality-control mechanisms, leading to dysfunction. Key molecular processes affected by aging include chromatin remodeling, transcriptional regulation, and post-translational protein modifications. Molecular aging research has led to the identification of aging clocks, particularly epigenetic clocks, which estimate biological age based on molecular signatures. Targeting molecular aging pathways holds promise for slowing aging and preventing age-associated diseases.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom