Microbiota dysbiosis aging describes age-associated imbalance in microbial communities that disrupts host–microbe homeostasis. Dysbiosis involves loss of beneficial microbes, overgrowth of inflammatory taxa, and reduced metabolic diversity. This imbalance compromises gut barrier function and promotes systemic inflammation. Microbiota dysbiosis aging contributes to metabolic dysfunction, immune decline, neuroinflammation, and increased disease susceptibility. Aging-related immune changes and altered intestinal environment exacerbate dysbiosis. Persistent dysbiosis reinforces chronic inflammation and accelerates biological aging. Understanding microbiota dysbiosis aging supports development of interventions that restore microbial balance and improve systemic resilience during aging.
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