Macrophage aging refers to age-associated changes in macrophage function, phenotype, and signaling. Aging macrophages exhibit altered inflammatory responses, reduced phagocytic capacity, and impaired tissue repair support. These changes promote chronic inflammation and reduced clearance of damaged cells. Macrophage aging contributes to impaired immune regulation, delayed wound healing, and increased disease susceptibility. Altered macrophage behavior also affects metabolic and vascular tissues. Understanding macrophage aging highlights innate immune dysfunction as a driver of age-related inflammation and tissue decline.
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Kenneth R Pelletier, University of California School of Medicine, United States
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Thomas J Webster, Brown University, United States
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