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World Aging & Longevity Conference
October 08-10, 2026
Loss of Heterochromatin Aging
Loss of Heterochromatin Aging
Loss of heterochromatin aging refers to age-related reduction of tightly packed chromatin regions that maintain genome stability. Heterochromatin silences repetitive elements and protects against genomic instability. With aging, heterochromatin structure deteriorates, leading to inappropriate gene activation and increased transcriptional noise. Loss of heterochromatin aging promotes DNA damage, transposable element activation, and epigenetic instability. This process disrupts cellular identity and contributes to senescence and inflammation. Loss of heterochromatin is considered a fundamental epigenetic hallmark of aging. Understanding this phenomenon provides insight into how chromatin architecture breakdown drives aging biology.
Committee Members
Kenneth R Pelletier
University of California School of Medicine, United States
Thomas J Webster
Brown University, United States
Jason Beckwith
BioTalent, United Kingdom WALC 2026 Speakers
Sergey Suchkov
N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation
Jose Cordeiro Mateo
International Longevity Summit, Spain
Ashot Khachatryan
National Academy of Sciences of the Republic of Armenia, Armenia
Utpol Das
University of Texas Medical Branch at Galveston, United StatesSubmit your abstract Today
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom