Longevity determinants are biological, environmental, and behavioral factors that influence lifespan and survival patterns. These determinants operate across molecular, cellular, and systemic levels. Genetic architecture, metabolic efficiency, stress resistance, immune balance, and regenerative capacity all contribute to longevity outcomes. Longevity determinants interact dynamically rather than acting independently. Environmental exposures and lifestyle behaviors modulate biological aging rate and disease susceptibility. Longevity determinants help explain why lifespan varies widely among individuals. Understanding longevity determinants supports identification of modifiable factors that promote extended survival while preserving functional health. This concept shifts focus from lifespan prediction toward intervention-based longevity optimization.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom