Lipotoxicity aging refers to accumulation of excess lipid species in non-adipose tissues during aging. When lipid storage capacity is exceeded, toxic lipid intermediates damage cellular structures. Lipotoxicity aging impairs mitochondrial function, induces oxidative stress, and disrupts cellular signaling. This process affects muscle, liver, pancreas, and heart, contributing to metabolic decline and organ dysfunction. Lipotoxicity aging links altered fat metabolism to cellular damage and inflammation. Understanding lipotoxicity aging highlights the importance of lipid balance in maintaining cellular health and metabolic resilience during aging.
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