Laminopathies Aging

Laminopathies aging refers to age-associated conditions linked to dysfunction of nuclear lamins, structural proteins that maintain nuclear shape and genome organization. Nuclear lamins play a critical role in chromatin anchoring, gene regulation, DNA repair, and mechanical stability of the nucleus. During aging, alterations in lamin structure and expression disrupt nuclear integrity and chromatin organization. These changes lead to transcriptional instability, impaired DNA repair, and increased cellular stress. Laminopathies aging illustrates how defects in nuclear architecture accelerate biological aging and promote tissue dysfunction. Even subtle lamina alterations can amplify age-related decline by affecting multiple cellular processes simultaneously. Understanding laminopathies aging provides insight into structural drivers of aging and highlights nuclear stability as a key determinant of cellular longevity and tissue resilience.