Innate immunity aging refers to functional decline in first-line immune defenses such as macrophages, neutrophils, dendritic cells, and natural killer cells. Aging impairs pathogen recognition, phagocytosis, and inflammatory resolution. These alterations reduce rapid immune responses while promoting prolonged inflammatory signaling. Innate immunity aging also affects tissue repair and immune surveillance. Impaired innate immune responses contribute to increased infection risk and delayed recovery in older individuals. Understanding innate immunity aging provides insight into early immune dysfunction and supports development of interventions to restore immune balance.
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