Immune remodeling aging refers to age-associated reorganization of immune system composition and function. Aging shifts immune cell populations toward memory and senescent phenotypes while reducing naïve cell diversity. Immune remodeling aging alters inflammatory balance, reducing pathogen defense while increasing chronic inflammation. This remodeling affects both innate and adaptive immunity. Altered immune architecture contributes to infection susceptibility, vaccine inefficacy, and chronic disease risk. Understanding immune remodeling aging provides insight into systemic immune adaptation and dysfunction during aging.
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