IGF 1 signaling aging refers to age-associated changes in insulin-like growth factor 1 pathways that regulate growth, metabolism, and cellular survival. IGF 1 signaling is essential during development but excessive activity later in life is linked to accelerated aging and increased disease risk. Reduced IGF 1 signaling promotes stress resistance, improved metabolic regulation, and extended lifespan in multiple organisms. This pathway influences aging by regulating cell proliferation, nutrient sensing, and repair mechanisms. IGF 1 signaling aging reflects a shift from growth-driven processes toward maintenance and longevity. Understanding this balance is critical for identifying interventions that delay aging while preserving physiological function.
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Kenneth R Pelletier, University of California School of Medicine, United States
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