Hormonal aging describes age-related alterations in hormone production, secretion patterns, and tissue responsiveness. Aging affects endocrine axes regulating growth, reproduction, metabolism, stress response, and circadian rhythms. Hormone levels often decline or become dysregulated, leading to impaired feedback control. Hormonal aging contributes to sarcopenia, bone loss, metabolic instability, immune dysfunction, and reduced stress tolerance. Interactions between hormonal aging and inflammation amplify functional decline. Because hormones coordinate inter-organ communication, endocrine disruption has systemic consequences. Understanding hormonal aging emphasizes the importance of endocrine balance in maintaining physiological integration, adaptability, and healthspan during aging.
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