Hormesis aging describes beneficial adaptive responses triggered by mild, transient stress during aging. Low-level stressors activate protective pathways that enhance cellular repair, stress resistance, and metabolic efficiency. Examples include metabolic stress, physical exertion, and temperature variation. Hormesis aging reflects the principle that limited challenge strengthens biological systems. With aging, hormetic responsiveness may decline, reducing adaptive capacity. Understanding hormesis aging supports strategies that leverage controlled stress exposure to promote resilience and slow functional deterioration. Hormetic mechanisms play a key role in longevity biology by enhancing survival pathways and reducing vulnerability to chronic stress.
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Kenneth R Pelletier, University of California School of Medicine, United States
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Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
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Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
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Arthur J Siegel, McLean Hospital, United States
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