The hallmarks of aging are a set of fundamental biological processes that drive aging and age-related decline. These hallmarks provide a conceptual framework for understanding how molecular and cellular damage accumulates and translates into functional impairment. They include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, mitochondrial dysfunction, dysregulated nutrient sensing, and altered intercellular communication. Each hallmark contributes independently and interactively to aging. The hallmark framework has unified aging research and guided the development of targeted interventions. Studying hallmarks of aging enables identification of common mechanisms underlying diverse age-related diseases.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom