Gut immune aging describes age-related changes in immune surveillance and regulation within the gastrointestinal tract. Aging reduces mucosal immune responsiveness while increasing inflammatory signaling. Declining gut immune function compromises barrier integrity and pathogen defense. At the same time, excessive immune activation promotes chronic inflammation. Gut immune aging interacts with microbiome alterations, reinforcing dysbiosis and systemic immune imbalance. These changes influence nutrient absorption, metabolic regulation, and susceptibility to infection. Understanding gut immune aging provides insight into how localized immune decline contributes to systemic aging and disease vulnerability.
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