Growth hormone decline refers to progressive reduction in growth hormone secretion with advancing age. Growth hormone regulates tissue repair, protein synthesis, lipid metabolism, and body composition. Declining growth hormone levels contribute to reduced muscle mass, increased fat accumulation, decreased bone density, and impaired regenerative capacity. Growth hormone decline also influences immune function and metabolic regulation. Although reduced growth hormone may protect against certain age-related diseases, excessive decline limits tissue maintenance and recovery. Understanding growth hormone decline highlights trade-offs between growth signaling and longevity and underscores its role in musculoskeletal and metabolic aging.
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