Glycation end products aging refers to accumulation of modified proteins and lipids formed through non-enzymatic reactions between sugars and biomolecules. These products alter molecular structure and function, impairing protein flexibility and signaling. Glycation end products aging increases tissue stiffness, promotes inflammation, and disrupts cellular interactions. These modifications accumulate slowly and persist due to reduced turnover. Glycation end products aging contributes to vascular stiffness, skin aging, and metabolic dysfunction. Understanding this process highlights metabolic regulation as a determinant of molecular aging and tissue decline.
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