Genomic instability aging refers to the progressive accumulation of genetic alterations over time, including mutations, chromosomal aberrations, and structural DNA changes. Aging cells experience increased genomic instability due to continuous exposure to DNA-damaging agents and declining genome maintenance mechanisms. Oxidative stress, replication errors, and environmental insults contribute to persistent DNA lesions. As genomic integrity deteriorates, cells become more prone to dysfunction, senescence, apoptosis, or malignant transformation. Genomic instability is a major driver of aging phenotypes and age-related diseases, particularly cancer. Preserving genome stability is essential for long-term cellular function and organismal health, making it a fundamental aspect of aging biology.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom