Extracellular vesicles aging describes age-related changes in production, cargo, and biological effects of membrane-bound vesicles released by cells. These vesicles transport proteins, lipids, metabolites, and nucleic acids between cells, enabling intercellular communication. With aging, extracellular vesicle composition shifts toward inflammatory and stress-related signals. This altered cargo influences immune activation, metabolic regulation, and tissue remodeling. Extracellular vesicles aging contributes to propagation of aging signals across tissues and organs. Changes in vesicle release reflect cellular stress, senescence, and metabolic imbalance. Understanding extracellular vesicles aging provides insight into how systemic aging signals are transmitted at the molecular level.
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