Extracellular matrix aging refers to progressive deterioration of the structural network that supports cells and tissues. The extracellular matrix provides mechanical strength, elasticity, and signaling cues essential for tissue function. With aging, matrix composition changes due to reduced synthesis, increased degradation, and altered organization of structural proteins. These changes impair tissue resilience and disrupt cell–matrix interactions. Extracellular matrix aging contributes to tissue stiffness, fibrosis, and impaired regeneration. Accumulation of damaged matrix components further amplifies inflammation and cellular stress. Understanding extracellular matrix aging highlights how structural tissue scaffolds influence functional decline across organs during aging.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom