Exosomes aging refers to age-associated changes in small extracellular vesicles originating from endosomal pathways. Exosomes play key roles in transferring regulatory molecules between cells. During aging, exosomal cargo becomes enriched in inflammatory mediators, damaged proteins, and altered microRNAs. These changes influence gene expression, immune regulation, and tissue function in recipient cells. Exosomes aging contributes to spread of senescence signals and chronic inflammation. Altered exosome signaling affects stem cell niches, immune responses, and metabolic tissues. Understanding exosomes aging highlights vesicle-mediated communication as a mechanism for systemic coordination of aging processes.
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