Epigenetic aging refers to age-associated changes in epigenetic regulation that influence gene expression without altering DNA sequence. These changes include DNA methylation, histone modifications, and chromatin remodeling. Over time, epigenetic patterns drift, leading to altered cellular identity, impaired stress responses, and dysregulated gene expression. Epigenetic aging is strongly associated with disease risk, inflammation, and mortality and is considered a central driver of biological aging. Unlike genetic mutations, epigenetic changes are potentially reversible, making them attractive therapeutic targets. Lifestyle factors such as diet, physical activity, stress, and environmental exposures significantly influence epigenetic aging. Understanding epigenetic aging provides insight into how external and internal factors shape aging trajectories and health outcomes.
Title : Change your genes – Change your life: Epigenetics of longevity
Kenneth R Pelletier, University of California School of Medicine, United States
Title : Improving mobility and health in over 45,000 humans using nanomedicine
Thomas J Webster, Brown University, United States
Title : An introduction to alchemical facial acupuncture: Sparking the shen
Mary Elizabeth Wakefield, Chi-Akra Center for Ageless Aging, United States
Title : Decoding the secret of longevity through big data: Noncoding RNAs—not proteins—drive animal lifespan evolution
Anyou Wang, DIFIBER LLC, United States
Title : Aspirin guided by coronary artery calcium scoring for primary prevention in persons with subclinical coronary heart disease
Arthur J Siegel, McLean Hospital, United States
Title : When BMI misleads: Integrating body composition, biomarkers, and personalized interventions for cardiometabolic healthspan in aging Asian and European cohorts
Narendra Kumar, HeartbeatsZ Academy, United Kingdom